A/Prof Seth Masters is head of the Inflammasomes and Autoinflammatory Disease laboratory at The Walter and Eliza Hall Institute. He holds a joint appointment at Glaxosmithkline (UK) and is appointed as a fellow of the Viertel Foundation, HHMI-Wellcome Trust and the NHMRC.
The Masters laboratory studies the innate immune system, which can be activated to cause autoinflammatory disease. A particular focus in this area has been the inflammasome protein complex which generates the cytokines IL-1b and IL-18. Understanding the molecular basis of inflammasome activation has been clinically actionable, as several of these rare inherited rheumatic conditions have excellent responses to biologics that block IL-1b.